Have you ever been diagnosed with breast cancer?
Do you have a personal history of estrogen-dependent cancer (e.g., endometrial cancer)?
Have you ever had a blood clot in your leg (DVT) or lung (PE)?
Do you have a known clotting disorder (e.g., Factor V Leiden Mutation)?
Have you had a heart attack, stroke, or severe cardiovascular disease?
Do you have uncontrolled high blood pressure?
Do you have severe liver disease or unexplained liver function abnormalities?
Do you have explained vaginal bleeding that has not been investigated?
Do you have a high risk for hormone-sensitive cancers due to strong family history or genetic mutations (e.g., NRCA1/2)?
Has your doctor previously advised you against using HRT for medical reasons?